HEMOBLASTOSES AMONG LIQUIDATORS OF CONSEQUENCES OF THE CHERNOBYL ACCIDENT AND POPULATION IN THE MOST HIGHLY CONTAMINATED TERRITORIES OF RUSSIA MEDICAL. - презентация

1 HEMOBLASTOSES AMONG LIQUIDATORS OF CONSEQUENCES OF THE CHERNOBYL ACCIDENT AND POPULATION IN THE MOST HIGHLY CONTAMINATED TERRITORIES OF RUSSIA MEDICAL RADIOLOGICAL RESEARCH CENTRE RUSSIAN ACADEMY OF MEDICAL SCIENCES DIRECTOR – ACADEMICIAN OF RAMS A. F. TSYB 29 May – 3 June 2006, Kiev, Ukraine V.K. Ivanov, A.F. Tsyb, S.E. Khait, A.I. Gorsky, M.A. Maksioutov, N.V. Schukina NATIONAL RADIATION AND EPIDEMIOLOGICAL REGISTRY HEAD – CORR.-MEMBER OF RAMS V. K. IVANOV WHO Collaborating Centre of Radiation Epidemiology

2 Sources of the data Primary medical documents 1. Medical History 2. Out-patient card 3. Control card of dispensary follow-up 4. Notification about oncological disease 5. Record in the journal of KDL (text of myelogramm, cytochemical study, immunological, cytogenetics and blood cell culture study) 6. The journals of oncological offices of CRH 7. Pathological anatomy study (protocol of histological study) 8. Protocol of trepanobiopsy of bone marrow and biopsy of lymphatic node Diagnostic materials Blood smears Smears of bone marrow Histological preparations Health care service Rayon and municipal clinic (oncological consulting cabinet) Oblast clinic Oblast oncological dispensary Republican hematological Center

3 РОССИЙСКИЙ РАДИАЦИОННО- ЭПИДЕМИОЛОГИЧЕСКИЙ РЕГИСТР АРХИВ ГИСТОЛОГИЧЕСКИХ МАТЕРИАЛОВ Больной Л. Диагноз: острый миелобластный лейкоз

4 Structure of hemoblastoses among liquidators ( )

5 LEUKAEMIA AND MYELOMA CASES

6 Distribution of different types of leukemia I. among the liquidators ( ) II. for males with attained age years according to official statistical data in the Russia as a whole ( ) III. according to data of the Russian Hematological Center ( )

7 Structure of leukemia in different time periods

8 ESTIMATES OF RELATIVE RISK AMONG LIQUIDATORS

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10 LEUKAEMIA CASES

11 LEUKAEMIA CASES (children)

12 LEUKAEMIA CASES (adults)

13 LEUKAEMIA CASES

14 ESTIMATES OF RELATIVE RISK AMONG POPULATION

15 1. Potential risk group of radiogenic leukemia is defined, which contains liquidators with dose more then 150 mSv. 2. Risk of radiogenic leukaemia in the population of the highly contaminated areas of the Bryansk oblast during is positive, but statistically not significant. There is trend of leukaemia incidence with the dose for the overall population. 3. In the cohort of liquidators and the population of the most contaminated with radionuclides areas following the Chernobyl accident increase of the fraction of chronic myeloleucosis in the structure of leukemias were detected.