SUPPOSITORIES 1 Pharmaceutical and toxicological chemistry department SOUTH KAZAKHSTAN STATE FARMACEUTICAL ACADEMY Done by: Azimkhanova Balzhan Accepted by: Orynbassarov Yerzhan

Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve and exert localized or systemic effects. 2

SUPPOSITORIES: British Pharmacopoeia (BP) definition: Suppositories are solid, single-dose preparations. The shape, volume and consistency of suppositories are suitable for rectal administration. 3

Dose character: For rectal administration, one half to two or more times than the oral dose is given. - The correct dose of any drug depends on the rate of release from the suppository - Since the vehicle can change the rate of drug absorption, the amount of drug to be given in suppository dose depend on the vehicle, the chemical and physical from the drug. 4 i/Image:Suppositories_three_differ ent_sizes_2.jpg

Types: 1- Rectal suppository: 32 mm in length, cylindrical, have one or both end tapered. a) Adult rectal supp. Weight 2gm b) infant rectal supp.1gm 2- Vaginal suppository: pessaries, 5gm, usually oviform or cone shaped, weight from 3-5 gm 3- Urethral suppository: bougies 4gm and cm long for male and 6-7.5cm long for female., pencil shaped. 5

Therapeutic uses Suppository can be used for local or systemic effect. The action depends on nature of drug, concentration and rate of absorption Rectal suppository are intended for treatment of constipation and hemorrhoids. Suppositories are also administered for systemic action (analgesics, antispasmodics, sedatives & tranquilizers). 6

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